Serotonin, Nor-epinephrine, and novel mitigation of depression symptoms post cycle

TL;DR: Eat a balanced diet, get in the fucking sun, do your god damn cardio (preferably also in the sun), and supplement with vitamin E. Don't let me catch some post crop up in /r/PEDs about how you shoved a bottle of Lexapro up your urethra and now you hear colors. I won't care.

Serotonin and Me

I'd like to preface this article with a few things; As some of you may know, I'm diagnosed with Bipolar 1 and combat PTSD. Through my medical history I've been on a litany of prescription medications, most revolving around benzodiazepines, selective serotonin re-uptake inhibitors (SSRI) and Serotonin/nor-epinephrine re-uptake inhibitors (SNRI). This has given me a unique insight into mood regulation, as well as neuropathic pain management. Many of these drugs were introduced to me under medical observation while inpatient at psychiatric hospitals or the VA. I do not recommend fucking with these chemicals unless you are absolutely certain you can handle the consequences. Many of these drugs altered my perception of reality, or caused other, more serious side effects that required immediate medical attention. I cannot stress this enough, I'm not responsible for anything you may do to yourself after reading this article, which is good, because many of these medications you'd need a prescription for. This article stems from my own personal attempts to mitigate my ailments, as well as anecdotal research conducted through my use of SARMs.

That being said, follow me, down what may be the most ridiculous rabbit hole you dive into all week.

Serotonin and Nor-epinephrine: What can/do they do?

  • Nor-epinephrine (also known as nor-adrenaline) is a mono-amine found in the autonomic nervous system. It is associated with arousing situations and has been specifically cited in the development of both proactive and reactive aggression (sauce).The autonomic nervous system (ANS) is a control system that acts largely unconsciously and regulates bodily functions such as the heart rate, digestion, respiratory rate, papillary response, urination, and sexual arousal (sauce).
  • Serotonin (or 5-hydroxytryptamine (5-HT)) is a mono-amine neurotransmitter most commonly found in the GI track (about 90%) and contribute mostly to gastrointestinal motility, however, the rest is synthesized in serotonergic neurons of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. Modulation of serotonin at synapses is thought to be a major action of several classes of pharmacological antidepressants. (sauce 1) (extra saucey).

How are these affected by SARMs/Androgens?

Changes in mood associated with a decline in free plasma testosterone and the apparent mood-heightening effect of testosterone may be related to changes in density of the 5-HT2AR and the SERT (means serotonin transportation) in brain regions concerned with mood, mental state, cognition and emotion. The fact that the action of testosterone depends upon its conversion to estrogen probably explains why testosterone has no effect on the 5-HT2AR in regions of the brain, such as the caudate-putamen, where the aromatase enzyme is scarce (sauce).

Androgens also regulate some aspects of the mental condition through the minor population of AR/5-HTcoexpressing DRN neurons in both the rat and mouse.

Simply put, we need our testosterone to aromatize to fully reap the cognitive benefits it may express on our serotonin secretion. This may explain why many, but not all, of our community members have found their SARMs help promote feelings of wellness, as their rate of aromatization has not been altered due to exogenous hormones. Coincidentally, norepinephrine has been shown to increase testosterone aromatization in rats.

For sake of your eyes I've cut a large portion of this out (as I don't think it really matters), but there are many serotonin receptor agonists that may have an affect on their release in the brain. Many of these, in some function or another, are moderately affected through sex hormones and AR. List of serotonin receptor agonists.

From anecdotal experience, and witnessing testimony of users in our community, I believe the additional androgen receptor density we receive from our SARMs, and 'flooding' of testosterone back through our pituitary through recovery may lead some members to experience something called 'serotonin sickness' that I have experienced on and off multiple different prescription medications such as Celexa, Lexapro, Prozac (SSRI's), Cymbalta, and Effexor (SNRI's).

How can I manage my serotonin/norepinephrine naturally?

  • Metabolites α-tocopherol, tyramine and PABA sufficiently induce 5-HT in vitro and in vivo, and treatment with α-tocopherol reduces depressive-like behavior in pre-clinical models, and is a naturally abundant form of vitamin E, with reported therapeutic effects for several diseases (saucey sauce).
  • In rats, serotonin is highest during the light part of the light–dark cycle, and this state is driven by the photic cycle rather than the circadian rhythm.
  • Researchers showed that exercise increased tryptophan and 5-HIAA in rat ventricles, while more recent studies using intracerebral dialysis have shown that exercise increases extracellular serotonin and 5-HIAA in various brain areas, including the hippocampus and cortex, though it should be noted that conditioned rats did not experience such an increase in extracellular serotonin secretion.
  • Purified tryptophan increases brain serotonin, foods containing tryptophan do not (sauce).
  • Ironically, L-theanine appears to have a role in the formation of the inhibitory neurotransmitter gamma amino butrylic acid (GABA). GABA blocks release of the neurotrans- mitters dopamine and serotonin and may, therefore, have the key role in the relaxation effect (sauce). Conversely, theanine has also been shown to inhibit serotonin synthesis and increase serotonin degradation in the brain.
  • Proper diet and nutrition can help maintain the rate at which our precursor neurotransmitters regulate serotonin and acetylcholine

But Paint, what the fuck does this all mean?

I believe that our brains go through a fucking whiplash while cycling SARMs (and more or less AAS), and that with proper supplementation and awareness we may be able to mitigate the effects these have on us post cycle. Bringing my own experience into this research article again, I barely felt depressed or drained after cycle. At least nothing that I don't think I could outwardly attribute to not progressing in lifts/the mirror each week until I decided to cycle again. Much of this could even be contributed to placebo. I think a lot of this has to do with the fact that my entire day is based around managing my bipolar and containing my PTSD symptoms, which as I've learned go hand in hand with not only increasing serotonin and nor-epinephrine production, but the rate at which my body regulates them.

I had a huge bit about my experiences with different prescription medications, good and bad but I cut that shit out. Those can seriously fuck you up hard, even though I've thought about experimenting with a few of my leftovers if I ever do come across a post cycle crash. In the even that does happen, I guess I'll write another article.

Citations to quickly verify I didn't use bro science and Wikipedia (completely)

https://www.ncbi.nlm.nih.gov/pubmed/6290295

https://www.ncbi.nlm.nih.gov/pubmed/10385606/

https://www.ncbi.nlm.nih.gov/pubmed/2337799/

https://www.ncbi.nlm.nih.gov/pubmed/2413941/

https://www.ncbi.nlm.nih.gov/pubmed/11224400

https://www.ncbi.nlm.nih.gov/pubmed/6115400/

https://www.liebertpub.com/doi/pdf/10.1089/10762800151125092

https://sci-hub.tw/https://www.tandfonline.com/doi/abs/10.1271/bbb.62.816

https://www.ncbi.nlm.nih.gov/books/NBK209058/

https://en.wikipedia.org/wiki/Serotonin_syndrome

https://en.wikipedia.org/wiki/Serotonin_receptor_agonist