Collagen Synthesis: Part 2

Since writing my recent article on collagen synthesis, there are two that I clearly missed – BPC-157 and Curcumin. Thanks to /u/the_mad_canadian and /u/NattyFuckFace for pointing out these two compounds and being kind about my omission.

I’ll confess that I have never looked much into BPC-157, dismissing it from my mind as yet another experimental compound that may or may not show promise in human trials. But I’ve since seen anecdote after anecdote on /r/PEDsand elsewhere on just how effective this compound is. For the sake of this article, I’m going to focus on collagen synthesis, but it does seem to have other benefits.

At concentrations of 2 μg/mL in tendon fibroblasts which were then explanted, BPC-157 cells appeared to grow faster than fibroblasts not treated with BPC-157 within two days, reaching a significantly larger amount after one week.

What the fuck does that mean? Basically, the ability to produce more collagen increases.

The key is the fibroblasts, which are cells that produce collagen, among other things. More fibroblasts presumably means more collagen. And that seems likely given a second study which states:

PL 14736 (aka BPC-157) was more active in stimulating early collagen organization. It also stimulated expression of egr-1 and its repressor nerve growth factor 1-A binding protein-2 (nab2) in non-differentiated Caco-2 cells more rapidly than PDGF-BB. EGR-1 induces cytokine and growth factor generation and early extracellular matrix (collagen) formation, offering an explanation for the beneficial effects of PL 14736 on wound healing.

BPC-157 appears to be effective topically (when healing a wound), by injection, or orally. I’m not putting dosage information here because of lack of data on humans, sorry, as I can’t be sure of the minimum effective / maximum safe dose.

Curcumin on the other hand has been around for thousands of years, used in curry, medicine and food dyes. It reduces inflammation, and is a solid choice for supplementation if you don’t get much of it through your diet (and unless you live on the sub-continent, you probably don’t).

Curcumin significantly improved the healing properties as evidenced by extensive deposition of well-organized collagen fibers

Note that ‘well organized’ might not mean more collagen in this instance, but could increase mRNA (the thingy that tells collagen where to form) instead. However, I honestly think that the researcher wrote this in a confusing way, and that ‘extensive deposition’ means a higher than normal amount of collagen in the area of the sample.

There’s likely (many) more compounds out there increase collagen, so please feel free to let me know what I’ve missed and hopefully I will cover them in the near future.