Making Your Own Minoxidil / RU58841 Solution

This is a quick write-up on how to make your own Minoxidil / RU58841 formula, prompted by a question from /u/PopBottlesPopHollows. This combination is pretty common, since many folks are using both, especially on cycle. However if you wish to make your own solution without the minoxidil, you can use ethanol to do so. I don't see the advantage tbh given that the liquid minoxidil isn't all that pricey and works out cheaper than buying the Ethanol, but I'm sure there are use cases for doing it without the Minoxidil due to side effects.

I will caveat that per my RU58841 write-up, I don't recommend any DHT blocking/targeting/reducing compound unless also using exogenous test. This is out of an abundance of caution, mostly. We know that topically applied compounds can have systemic effects, and antiandrogens are somewhat indiscriminate in what they block.

What is Minoxidil?

Minoxidil is an antihypertensive vasodilator medication. Theoretically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase.

What is RU58841?

RU58841 is a nonsteroidal antiandrogen formerly under investigation, but since the patent ran out it’s no longer being evaluated. It blocks androgens from binding, such as DHT.

More on RU58841 here and addressing its mixed reputation.

Mixing Up Your Formula

Minoxidil comes in two forms, foam or liquid, and to do this you're gonna need the liquid. It can easily be bought on Amazon, drug store/chemist and even some grocery stores. The liquid comes conveniently in 60 ml bottles. I also assume you're rolling with the most popular dose of 5% strength 50mg/ml.

You will need the following at a minimum:

  • RU58841 powder / raws
  • Minoxidil liquid
  • Milligram scale

Ideally, you'll also have:

  • Stirring rod
  • Measuring beaker / cup
  • Funnel

Step by Step

Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. Place your beaker/cup bottle on top of the scale, measure out your 3 grams of RU58841 and place it inside. If you choose instead to add the RU direct into the Minoxidil, do it slowly and carefully (no shit).

Step 2: Combine it with the Minoxidil, with help from funnel if necessary.

Step 3: Shake and swirl the solution lightly until the RU58841 powder has completely dissolved inside the bottle, and the solution is completely clear.

Voila. You now have a bottle of Minoxidil with 50mg of RU58841 per ml of solution. Apply to scalp with a dropper or pipette once daily.