How To Make A 10mg/ml Solution

Want to skip the preamble and just want to know how to make a solution? Skip down to the heading ‘How To Make a 10mg/ml Solution’.

This is a common enough topic request, and I think we’ve been guilty of some gatekeeping in this area. I always took it as a given that folks would inevitably learn it for themselves: I had to learn by trial and error, and so should you.

The goal in this write-up is to correct that and provide a guide to making your first solution, as well as offering some options should that not be an option. There are infinite variations and iterations, and some that will work better for you. Be it because you wish to work in different quantities, have more (or less) supplies available, and are making use of what you have at hand. For example:

  • large mixing glass that can take larger quantities of PG
  • multiple dropper bottles, and you only want to make your solutions once, so you do a larger batch
  • substituting PG for Ethanol, because you like having a shot of alcohol in the morning, because your corporate drone office job is soul crushing and it’s the only way you can face the day

Whatever the reason, there’s no wrong and no right way to make your solutions, just some that might work better for you.

The Case For Mysterious Yellowish/White Powders

I am bias against pre-made solutions. I think vendors are selling solutions at a huge mark up without the customer realizing that they’re being ripped off. Yes, pre-made solutions are convenient, but as we’ll see, making a solution is not that challenging, and there alternatives. One thing is for certain: raws / powders are also around 3 times cheaper per dose.

Using a popular SARM vendor to illustrate this example and assuming a 5mg daily dose:

LGD4033 solution (300mg): $39.99, or $0.67 per dose

LGD4033 powder (1000mg): $37.99, or $0.19 per dose

(Personally, I think even their raw powder cost is pretty expensive, but what do I know? I’m just one of their competitors.)

Why Make A Solution?

A solution is the most reliable method of ensuring an accurate dose. The key is that the solvents we commonly use are something called miscible:

Propylene glycol, is a stable, colorless, odorless, viscous liquid... It is an excellent solvent because it is freely miscible with water yet dissolves hydrophobic substances.

Miscible refers to homogeneity of two substances. I.e. you will get a stable and consistent dose of both compounds when mixed together. There’s no risk of taking a dose and not getting enough or getting too much.

Why PG?

PG is recognized as safe and is used in a wide range of applications, including food and drugs. Among the glycols, propylene glycol has the lowest toxicity.

For most compounds, you can also use 151 (grain alcohol). There is a list of common compounds and what they are soluble in here. You will note that PG is almost universally soluble, another reason we’re using it as our example here.

It’s also cheap and commonly available in various sizes (just like traps).

How To Make a 10mg/ml Solution

Take your PG, 151, or whatever your solvent of choice is and mix it with your compound. Shake, stir, leave it overnight. Whatever is fine, you’re unlikely to harm the compound (unless you’re working with HCG or BPC or an otherwise ‘fragile’ peptide).

Using the brommunity data, we have a list of known successful concentrations that work (thanks bros, this is one of the most useful and undervalued items to come out of /r/PEDs). The thread is here, and the second tab of the spreadsheet has the concentrations.

Steps of making the solution can be broken out as follows:

Step 1: Weigh out 500mg of your compound, and using a funnel drop it in your dropper bottle/beaker/whatever you are putting it in to mix. If you’re lacking a funnel, get a piece of paper and make a cone.

Step 2: Weigh out 50mg of PG, and using a funnel pour it in to the same dropper bottle/beaker/ whatever.

Step 3: Mix. It may take some time to dissolve, in which case put it in a cupboard and go watch some TV, or hit the gym, or whatever.

Step 4: If not already in a dropper bottle, grab a funnel and pour the mixture into the dropper bottle

Voila.

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At this concentration, 1ml (1 dropper full) is equivalent to 10mg. Therefore:

  • 2 droppers = 20mg
  • 0.5ml dropper = 5mg
  • 0.25ml dropper = 2.5mg

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50ml of PG is convenient, because many dropper bottles are 2oz, and 50ml is about 1.7oz. When you displace the liquid by inserting the dropper into your bottle and screwing on the cap, it about fills it to the top.

Note: If you want to increase the concentration, add more than 500mg of the compound, or add less PG. Your concentration will then be ‘[Compound (in mg)] divided by [PG (in ml)]

I.e.

500mg/50ml = 10mg/ml

1000mg/50ml = 20mg/ml

Alternatives to Solutions - using a scale

Hey Comic, solutions are great and all, but I can’t be playing Walter White around the wife. What alternatives are there?

There’s no inherent advantage or activation that a solution gives a compound other than making it easy to dose accurately. If your dose is high enough (>10mg) you can measure out the powder using a mcg scale and knock it back. There are many available for $20-$40.

A mcg scale has a margin of error of a few mg, making it inconsistent for doses <10mg. For doses greater than 10mg, the variation in dose should be nbd for most folks.

Alternatives to Solutions - capping

Capping is a pain in the ass. I’ve done it once, and capped a couple hundred MK677 capsules using this popular device, and it took me an hour to do. Maybe you get better at it in time, but I haven’t given it another shot.

There’s an instructional video showing a little girls hands doing it in about 2 and a half minutes. Not included here is calculating the volume of the caps, mixing up the powder with a filler (flour or whey typically) and then tipping it into the caps and proceeding to lose about 20% of it on the floor.

Maybe you will have better luck than I did (or smaller hands), but I can’t recommend it.

Alternatives to Solutions - mixing with whey or flour

I ‘discovered’ this when I gave up capping, and had a bunch of MK677 raws left over already mixed in with whey (I think it was a ratio of 1 part MK677 to 4 parts whey). I put it in a small jar, and from that point forward I could weigh out 50mg of my mix, instead of weighing out just 10mg of MK677. The 50mg was easier to measure out than 10mg, and I noticed no difference in effects.

You’ll still need a mcg scale for this method, and after weighing it out just throw it in my mouth.

Let me be clear when I say that this method is not best practice and holds the risk of the dose being concentrated in some parts of the mix (i.e. not miscible). Make sure to shake it up real well before dosing (I actually used a mortar and pestle to grind the powder more finely, improve how well the compound was mixed in with they whey).

So What?

That’s it bro. You’ve saved yourself money in the long run, and given yourself control over your dose. You know for sure that it’s been done correctly with the right amount of compound, rather than half-assed by someone in their garage while they were high.