YK11 Mini Update + Detection

/u/mike_hunt_hurts found this 2018 study where researchers sought to determine a detection method for YK11 in humans. To achieve this, researchers gave it to a human volunteer - the first instance that I am aware of (if you know of others please lmk). As usual, they focused on only tangentially interesting points, but given the lack of human data that it was done at all is noteworthy. Previous write up on YK11 available here.

Due to its (YK11) steroidal backbone and the arguably labile orthoester‐derived moiety positioned at the D‐ring, substantial metabolic conversion in vivo was anticipated...

Parsing out the buzzwords, what’s interesting is their expectation of it having a short half-life and the note on its steroidal backbone

as described also for various androgens. The metabolism of anabolic androgenic steroids comprising a 19-nor-steroidal core structure has been investigated in great detail… YK11 also exhibits a 19-nor-steroidal nucleus.

Lots of compounds have this backbone - cholesterol is one example.

Deuterated YK11 was administered orally (8 mg, dissolved in ethanol/water 30/70 v/v) to one healthy male volunteer… After a wash out period of 4 weeks, the same volunteer administered 5 mg YK11 (0.5 mL of the purchased product dissolved in 20 mL of water)...

There are no notes of adverse effects, impacts on composition, or really anything about the subject. For those concerned with detection times, urine samples were frozen, and then thawed with glucuronidated and sulfated detectable for >48 hours and unconjugated metabolites <24 hours.

So what?

For the limited population that is concerned about detection, be aware that this is now possible. For the rest of us, we have no useful data coming out of this study other than ground has been broken in regards to administration to humans, and confirming that the compound has a short half-life.