Molecular Hydrogen: Potential Lipid Support on Cycle?

In a nutshell, my interpretation is that drinking hydrogen water may be a way to help support lipid profile during a cycle.

During the first study, patients drank between 450-500 ml 2x per day with an H2 concentration of 20-25 mM.

Question: I am unsure what the approximate mM concentration of a standard molecular hydrogen dissolving tablet would be I think 5 ppm hydrogen water would be like 2.5 mM? (5 mg/L / 2 mg/millimole = 2.5 millimole / liter)

  • Does this mean a standard hydrogen tablet may not suffice?

My conclusion is that hydrogen water may support lipid profile on cycle. However, the relative impact of hydrogen water on lipids may or may not be enough to make a difference in comparison to the negative impact of various SARMs and/or AAS. It could potentially be effective for some substances and not others. IMO it is worth a shot! Though some may find the cost prohibitive.

Abstract

...The objective of this study was to characterize the effects of H2-rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H2significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-α-induced apoptosis. Further, we found consumption of H2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.

from abstract

Intake of hydrogen-rich water was associated with significant decreases in the levels of modified low-density lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15.5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase.

conclusion of study

H2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDLantiatherosclerotic functions, and has beneficial lipid-lowering effects. The present findings highlight the potential role of H2 in the regression of hypercholesterolemia and atherosclerosis