MK-677 Has Not Been Abandoned

In this article, I decided to take another look at MK677. For past related articles:


Growth hormone increases IGF1. MK677 helps increase the size of the GH spikes that our body produces. I’ve taken it as a given that this is a good thing… right?

One of its (Growth Hormones) best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I)

Well, unfortunately increasing GH and IGF1 does not seem to actually do anything beneficial in healthy humans.

Although benefits of GH administration have been reported for those who suffer from GH deficiency, there is currently very little evidence to support an anabolic role for supraphysiological levels of systemic GH or IGF-I in skeletal muscle of healthy individuals…

That said…

In contrast, the hypertrophic effects of muscle-specific IGF-I infusion are well documented in animal models and muscle cell culture systems.

Odd. So increasing IGF1 levels in humans does not improve muscle growth (or at least no current evidence), but it does for animals and in petrie dishes? That’s a gap yet to be solved.

The evidence that GH has little effect in healthy adults is pretty well established: Rudman showed in 1990 and 1991 that GH administration results in increased lean body mass and decreased fat/muscle ratio in elderly subjects. I.e. those with diminished GH. A few years later in 1994 and 1996 it was showed that in healthy elderly men strength gains were not different between those with a placebo and those on HGH, and followed a resistance exercise program. This has since been replicated multiple times.

So why do athletes abuse GH in such numbers if it does nothing in healthy folk that do not have a clinically established need for it?

Collagen and bone improvements could be one reason, as well as injury recovery. And perhaps it’s effective when stacked with other PEDs(?). Why do we, /r/PEDs members, use MK677 to boost GH? I’m not too sure. I had assumed it helped with the building of muscle, but that does not seem to be the case.

Supraphysiological GH in adults can lead to a condition called acromegaly characterized by overgrowth of bony tissue (brow and lower jaw protrusion, enlargement of the extremities), osteoarthritis, carpal tunnel syndrome, headaches, cardiomyopathies, hyperglycaemia, hypertension and diabetes mellitus.

Cheerfully, IGF1 might be a cause of cancer. Folks with very low levels of IGF1 have a reduced risk of developing cancer. And that seems to jive with the finding that HGH use might increase mortality associated with cancer.

Given how MK677 works (enhances the size of the spikes of GH, rather than injecting a steady supply of GH) I’m not necessarily worried about the latter study, but certainly the former (IGF1) is something you may wish to consider. Perhaps do not run MK677 alongside Cardarine, just to be safe.

So should you take MK677 as a 25-50 year old? I’m not convinced that it’s a valuable PED for the average gym rat. Perhaps you could use it to help bulk (given its effect on appetite), sleep and recovery (looking at you, trensomnia), and the other benefits we already covered. I don’t think it’s good for a cut, despite GH having a reputation for preserving lbm because of its effects on appetite. So I’m left to make an unpopular conclusion: don’t bother.