MK-677 Effective Dose

Conclusion: 10mg-25mg every day

MK-677 orally-active non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. Admittedly, I understand very little of what this means, but basically it increases the secretion of GH and insulin-like growth factor 1 (IGF-1). It produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.

In a double-blind rising-dose design, subjects received once daily oral doses of 10 or 50 mg MK-677 or placebo for 4 days over two treatment periods separated by at least 28 days. Four subjects received placebo and 10 mg/day MK-677 in a cross-over fashion in periods 1 and 2. Five subjects received 10 mg and then 50 mg/day MK-677 in a sequential, rising-dose fashion in periods 1 and 2, respectively…The drug was generally well tolerated, with no significant changes from baseline in circulating concentrations of cortisol, PRL, and thyroid hormones.

At 10mg, a 52% increase in IGF-I, and 79% increase in GH

At 50mg, a 79% increase in IGF-I, and 82% increase in GH


The relatively small delta between the two doses indicates a compound that has a non-linear relationship with dose, but instead efficiency will drop as dosage is increased. To minimize risks and side effects, those who choose to run the compound would be advised to dose between 10mg – 25mg every day.