LY305: Transdermal SARM
A liability of SARMs is suppression of HDL, otherwise known as good cholesterol. HDL reduces risk for heart disease. A good ELI5 is on WebMD.
However, taking SARMs non-orally might help reduce or eliminate this undesirable trait, and perhaps others. User research seems to indicate this is viable, with an increasing number injecting SARMs (/u/MezDez) and I still won’t confirm or deny if I’m administering my own through anal insertion. In this case though LY305 is bioavailable through transdermal administration… or, it puts the lotion on its skin.
A phase 1 study took 63 healthy volunteers, 12 who took a placebo, and the balance took were provided LY305 in a gel to be used transdermal-ly on the torso or armpit, with the armpit seemingly offering more stable levels. There were ‘minimal signs of adverse events at the site of administration’, with an assortment of events with the common theme of skin irritation of some kind but was not dose dependent.
Researchers note a decrease in total testosterone in females and males, but honestly looking at the tables it's pretty minor, with the men staying in normal range. In men, the difference between day 1 & day 28 was 18.83nmol/L (528ng/dl) and 15.08 nmol/L(436ng/dl) respectively for the 180mg group. This modest dip result was true in every other group, including the ladies. See for yourself.
The researchers did not measure lbm% changes, but as SARMs have demonstrated significant increases in lean body mass, I’m not too disappointed that the researchers didn’t take this extra step. We know that SARMs are effective, and in this case LY305 is established as relatively safe up to and including a dose of 360mg. Dialing the effective dose for performance enhancement is rarely done by the researchers, and more often than not is done by the enthusiastic amateurs (i.e. you and me).
Assuming supply of this compound can be found, application of this product represents the next challenge. Mixing it up into a gel is a bit of an unknown, though this YT video sheds some light on how it might get done in a lab.
If I didn’t have an inventory of compounds in my bathroom already that would make some pharmacies jealous, I’d be willing to give this a shot without waiting for additional clinical trials (which we’re likely waiting years for). Based on what we know about the safety and action of SARMs to date, the risk seems low and the benefits to HDL are significant in improving our long term health.