ITPP: Increases Endurance by 57%

After badgering /u/NattyFuckFace to post about cardio related PEDs, I started getting curious and doing my own reading about ITPP, or myo-Inositol trispyrophosphate. There’s a great journal article written on this subject which helped me gain a better understanding on ITPP since starting research this afternoon if after reading this you want to dive deeper still.

The TL:DR on this compound is that it gives you more endurance by increasing the available oxygen to muscles. I’ll spare us all the extensive proof the journal article lays out on how they determined that more oxygen was being made to the muscle, but instead concentrate on the data and dose recommendation.

In mice, ITPP applied via injection increased maximal exercise capacity by 57%. For mice with heart damage (induced?), exercise capacity increased by 63% presumably because the baseline was lower. When dissolved in water and taken orally, maximal exercise increased by 34%.

How does it work?

ITPP decreases the oxygen binding affinity of Hb (hemoglobin), increases tissue oxygen delivery… thus (is) an attractive candidate for the therapy of patients with reduced exercise capacity

Or for degenerates like ourselves

ITPP does not impact blood pressure or heart rate at least not in the animal trials, seemingly having no direct vascular or cardiac effects. For those looking for compound to help preserve cardiac health on cycle, ITPP will only help indirectly, through increasing muscle endurance, which ideally should help you go longer and faster (heh) in your cardio workouts. It’s not going to preserve your lipids like Cardarine would, for example, through any direct action. That might be OK though, since it doesn’t seem to carry the cancer risk: ITPP is currently in clinical trial for patients to reduce the size of tumors and prolong survival.

We don’t have human dose data just yet, but we can get a rough indication from the animal trials. In exhibit A you can see the dose dependent nature of ITPP. Exhibit B shows us that the effectiveness in increasing endurance plateaued between the two higher doses of 2g/kg and 3g/kg. Doing the conversion of this dose end up with 0.16g/kg as the optimal human dose.

HED (mg/kg) = Animal dose (mg/kg) x (Animal Km/Human Km)

HED 0.16g/kg = 2g/kg x (3/37)

That’s 0.16g/kg by in vitro. It’s not clear to me if taken orally if we should increase this to offset the decline in efficiency and that’s what I’m leaning toward unless someone can share a really good reason not to do so. It also has a half-life of 5 days. So kids, that’s 0.16g/kg x twice per week if you’re injecting, or 0.27g/kg x twice per week if you’re taking it sublingual (due to it being less bioavailable - see paragraph 3). Edit: that all said, this dose is far higher than what is usually taken. See comments and update below.

If I didn’t have a gram of Cardarine sitting in my drawer calling my name, I’d add it in to my cycle immediately. Despite this PED’s narrow focus, ITPP should be of interest to most PED users.

UPDATE seems that the conversion dose is extremely high, and that a more reasonable dose is 500mg x 3 times per week. In addition anecdotes suggest that it does lower heart rate. Converting doses is often inaccurate, and its more of a guide. It seems likely that the converted dose is off in this case.