Enclomiphene: Valid For TRT & Fertility Aid

TL:DR enclomiphene has its uses, not for B&C’ing, probably not for cycling, but as an alternative to TRT or even as a fertility aid.

Because of the antagonistic effects of enclomiphene, the drug has the potential to increase serum testosterone levels in men with secondary hypogonadism by restoring physiological endogenous testosterone secretion while maintaining testicular volume and, potentially, spermatogenesis.

Increase testosterone (relatively) naturally, and while (probably) maintaining fertility. Sounds a little like clomid, which is not surprise since it IS the trans-stereoisomer of clomiphene citrate, where the clomid molecule is arranged at a different angle when it binds with the estrogen receptor.

The compound also exhibited an unanticipated favorable effect on fasting plasma glucose; this result has been accompanied by rapidly accumulating evidence from other researchers for a bidirectional relationship between low serum testosterone and obesity/metabolic syndrome (syndrome X) in men.

(Put the ice cream down, fatty.)

Short-term clinical safety data for enclomiphene have been satisfactory and equivalent to safety data for testosterone gels and placebo. Enclomiphene demonstrates promise in the management of secondary hypogonadism associated with obesity, metabolic syndrome and, possibly, infertility, and should undergo placebo-controlled, randomized clinical trials for these indications.

So it’s safe, and has a wide variety of uses, without the common side effects of testosterone. But is it useful for performance enhancement? Firstly, it is not a steroid, but a estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. In other words, your balls produce more testosterone, presumably through an increase in FSH and LH.

A 2013 study (n=12) compared enclomiphene citrate as an alternative to topical testosterone. While I question the researchers choice in using topical testosterone as the control due to its spotty record when compared to IM administration, there’s no doubt that the result shows that enclomiphene is a valid alternative. After 6 months, testosterone levels for the gel were on average 545pg/dL, while enclomiphene was at 525pg/dL, with the latter showing higher LH, FSH and higher sperm concentrations.

A 2014 study (n=113) ran a similar test, and again we see an increase in LH, this time dose dependent. The test gel had a decrease in LH of -2.4miU/mL while 12.5 mg and 25mg of enclomiphene increased 4.8 and 6.9 miU/mL respectively. These results were mirrored with FSH, though sperm concentration seems to peak at 12.5mg daily, with 25mg having a negative impact compared to baseline values.

What we do NOT see, however, is a dose dependent change in total testosterone. The topic gel increased testosterone by 253.7ng/dL, 12.5mg of enclomiphene increased test by 258.5ng/dL, and oddly 25mg increased test by the lower amount of 197.3ng/dL.

Assuming that the study was not flawed in some way, this shows that 12.5mg of enclomiphene is the sweet spot, with 25mg providing no benefit. However, I do question this compounds use as a PED given the limit of its increase to test. Instead, it seems it should occupy a fertility and HPTA recovery function for those coming off of exogenous testosterone OR a TRT alternative where the user does not pair this with additional exogenous testosterone.

This post was prompted by this post which in turn was based on this. Baseline of testosterone for /u/SpaceBound91 is 776ng/dL, and post 4 weeks of enclomiphene was sitting at 1148ng/dL. In my opinion, this user is very fortunate to have a relatively high baseline, probably as a result for the healthy and active lifestyle he describes. This 47% increase in testosterone puts him outside of this labs range. For comparison, it’s a little above where I sit in my trough (5-7 days post last injection) on 200mg TRT. Performance enhancing? Not really, but I bet he feels good on it. I also think it may be a little atypical given the average test result in the 2014 study, and caution others that they may not achieve the same result, especially if their baseline is on the lower end of the normal range.

I’m not going to be dropping my vials for this compound, at least not yet. But I might, one day, when the wife demands that second kid and I temporarily stop injecting due to TRT's impact on fertility. As for you, is this a good compound? That depends on where you’re at: if you are B&C’ing, this is not for you. If you are doing SARM only cycles or are looking at alternatives to TRT this is a viable option.