Brassinosteroids: Laxogenin & 28-Homo

Disclaimer: I have no background in biology, chemistry, pharmacology, medicine etc. Any data presented is not advice, and I do not advocate the use of any illegal compounds. I have a potential conflict of interest: sale of related products.

I've seen an increasing amount of promotion for Laxogenin, and some really daft claims about its effectiveness. In short, there's no evidence for Laxogenin, though 28-Homobrassinolide looks like it has some potential. Both are a kind of plant steroid, called brassinosteroids.

Laxogenin and brassinosteroids in general are plant-derived and 'structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals.'

Laxogenin

There's next to no research performed on Laxogenin. Searching for it on Google Scholar produces no results (searching for Laxogenin and Laxogenin protein synthesis produces a only marginally relevant info). Be skeptical of any site making outrageous claims on this compound and I found many in researching this compound...

1: https://athleticmuscle.net/laxogenin-supplements/

2: https://blog.priceplow.com/laxogenin#What-are-the-potential-side-effects

Holy misleading statements, Batman!

There is, however, one direct study done on it as a potential anti-cancer compound.

28-Homo

That said, another brassinosteroid called 28-Homobrassinolide (no homo) showed the following results in rats:

  • a 6.7% increase in strength over control
  • 10mg/kg and 20mg/kg gave similar IGF-1 levels as a 10nM of Insulin.
  • In vitro, 1uM increased protein synthesis by 2.3% above control, and increased dose dependent until 10-20uM which increased protein synthesis by 34.9% and 36.9% respectively.
  • An apparent increase in nitrogen retention.
    • Groups treated with 20mg/kg increased body weight by 18.3%, and 60mg/kg increased body weight by 26.8%, with no significant increases in food when adjusted for body weight.
    • Lean body muscle (i.e. muscle) increased by 7% and 14.2%
    • Fat was reduced by 3.9% and 4.9%.
    • Low androgenic activity (i.e. limited or no side effects typically associated with steroid use)

28-Homo is definitely of interest following this study. I also really like the name.

So What?

There's no science to indicate that Laxogenin is effective, while anecdotes on it are mixed. 28-Homo seems interesting. If you do choose to use PEDs, I think there are better and more well known options out there.

https://www.reddit.com/r/PEDsR/comments/cdoeu7/brassinosteroids_laxogenin_28homo/