Artemisia Iwayomogi: attractive supplement nearly impossible to source
Artemisia iwayomogi, which I will confusing refer to as AI here on out. TL:DR appears very promising in terms of its health benefits, with little risk.
Props to Examine.com for their excellent collection of sources on this topic which I used as my starting point. Basic summary of preliminary results:
- Improves lipid metabolism - in cultured primary human skeletal muscle cells, treatment of 95 ethanol extracted AI increased expression two PPARδ-regulated genes (similar to cardarine), and genes acting in lipid efflux and energy expenditure. High-fat diet-induced obese mice model further indicated that administration of 95EEAI attenuated diet-induced obesity through the activation of fatty acid oxidation in skeletal muscle. There was no improvement in glucose levels, however.
- May be anti-inflammatory - Artemisia Iwayomogi appears to downregulate 19% of the gene products upregulated by proinflammatory LPS while upregulating 48% of the genes that are downregulated by LPS
- Decreases rate of immune cell death - polysaccharide (present in this compound) impacts how quickly thymocytes (cell state prior to becoming a T cell)
- Anti-allergenic - dose dependent reduction in histamine
- Inhibits peroxynitrite formation - Peroxynitrite can cause cell death, carcinogenesis and aging. AI can inhibit this.
- Liver protecting - inhibits fatty acid synthase and a bunch of other hepatic activities. Lowers cholesterol concentration, increased HDL as earlier noted, decrease in triglycerides
- Slows cancer growth - induces death of KB cells
Dose seems to be effective at 200mg/kg or less, with effects of the compound being dose dependent, mostly. This converts to being 32mg/kg, or 3200mg for a 100kg person.
There are no human trials and side effects are unknown at high doses. My speculation is that this is very side effect friendly, which I conclude because this is a herb that’s been used in foods and medicines ‘for centuries’ in Korea. As it’s not a manufactured compound we’re unlikely to see any human trials since there will be no pharma companies lining up to jump through the FDA hoops. Bro-anecdotes on sides, therefore, are highly valued.
The only problem in adding this in as a daily supplement is its limited availability. It’s part of the artemisia genus which contains some 400 varieties of plant including sage and mugwort and I couldn’t even find the the iwayomogi plant itself for sale in North America. I’d be skeptical of any PED supplier who suddenly starts offering artemisia iwayomogi given how difficult it seems to find the plant or bulk powder for sale, as well as how similarity its effects are to cardarine meaning substitution is a high risk.
Next time someone goes to Korea please smuggle some seeds back in for me. And if a customs agent ever reads this, I’m totally joking. But not really.